Merative Annotator for Clinical Data Container Edition

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SNOMED Clinical Terms® Version: SNOMEDCT_US_2022_03_01 March 1, 2022

This Program includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO). All rights reserved. SNOMED CT®, was originally created by The College of American Pathologists. SNOMED and SNOMED CT are registered trademarks of the IHTSDO.

The program described in this document also includes the vocabulary sources listed in the table below from the UMLS Metathesaurus, release 2022 AA. Some material in the UMLS Metathesaurus is from copyrighted sources of the respective copyright holders. Users of the UMLS Metathesaurus are solely responsible for compliance with any copyright, patent or trademark restrictions and are referred to the copyright, patent or trademark notices appearing in the original sources, all of which are hereby incorporated by reference.

Table 1. Additional UMLS Vocabulary Sources
AIR93AI/RHEUM. Bethesda, MD : National Library of Medicine, Lister Hill Center, 1993
ALT2009ABC Coding and Terminology. 9th. Albuquerque, NM: ABC Coding Solutions - Alternative Link, 2009
AOD2000Alcohol and Other Drug Thesaurus. 3rd. ed. [4 Volumes.] Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism (NIAAA) and Center for Substance Abuse Prevention (CSAP), 2000
AOT2003Authorized Osteopathic Thesaurus. Educational Council of Osteopathic Principles of the American Association of Colleges of Osteopathic Medicine: Chevy Chase MD, 2004
ATC_2021_21_03_01 (updated)WHO Collaborating Centre for Drug Statistics Methodology, Anatomical Therapeutic Chemical (ATC) classification system, 2021 Oslo, Norway
CCS2005Clinical Classifications Software (CCS). Release Date: April 2005. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD
CCSR_ICD10CM_2022 (updated)Healthcare Cost and Utilization Project (HCUP), Clinical Classifications Software Refined for ICD-10-CM, Agency for Healthcare Research and Quality (AHRQ), October 2021, Rockville, MD
CCSR_ICD10PCS_2022 (updated)Healthcare Cost and Utilization Project (HCUP),Clinical Classifications Software Refined for ICD-10-PCS, Agency for Healthcare Research and Quality (AHRQ), October 2021, Rockville, MD
CDCREC_1.2CDC, National Center for Health Statistics, Race & Ethnicity - CDC, Atlanta, GA, December 27,2017
CHV2011_02Consumer Health Vocabulary, 2011.
COSTAR_89-95Computer-Stored Ambulatory Records (COSTAR). Boston MA: Massachusetts General Hospital, 1989-1995.
CSP2006Computer Retrieval of Information on Scientific Projects (CRISP). Bethesda MD: National Institutes of Health, Division of Research Grants, Research Documentation Section, 2006.
CST95Coding Symbols for Thesaurus of Adverse Reaction Terms (COSTART). 5th ed. Rockville MD: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, 1995.
CVX_2022_02_14 (updated)National Center for Immunization and Respiratory Diseases, CVX Code Set, Atlanta, GA, February 14, 2022
DRUGBANK5.0_2021_01_29 (updated)DrugBank 5.0, OMx Personal Health Analytics Inc., February 03, 2022, Edmonton, Alberta, Canada, Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1 34(Database issue):D668-72
DXP94DXplain (An expert diagnosis program). Boston MA: Massachusetts General Hospital, 1994
FMA4_15Jose Leonardo V. Mejino Jr., M.D., Cornelius Rosse, M.D., DSc, Foundation Model of Anatomy, v4.6.0 Department of Biological Structure, University of Washington, April 2019
GO2021_05_01Gene Ontology, Gene Ontology Consortium, May 1, 2021
HCPCS2022 (updated)Healthcare Common Procedure Coding System (HCPCS), 2022 Baltimore, MD Centers for Medicare & Medicaid Services 2022
HGNC2021_03Gray KA, Yates B, Seal RL, Wright MW, Bruford EA, HGNC Database, The HUGO Gene Nomenclature Database, European Bioinformatics Institute Wellcome Trust Genome Campus, March 21, 2021 United Kingdom
HL7V2.5_2003_08_30Health Level Seven Vocabulary (HL7). Ann Arbor MI: Health Level Seven, 1998-2002
HL7V3.0_2021_12 (updated)Health Level Seven (HL7) Vocabulary, Ann Arbor, MI, December 2, 2021
HPO2021_10_10 (updated)The Human Phenotype Ontology (HPO), The Human Phenotype Ontology Consortium, October 10, 2021
ICD10PCS_20222Centers for Medicare and Medicaid Services, International Classification of Diseases, 10th Revision, Procedure Coding System, Baltimore, MD, 2022
ICD9CM_2014National Center for Health Statistics (NCHS), ICD-9-CM: International Classification of Diseases, Ninth Revision, Clinical Modification, FY 2014 Medicare Addendum United States, October 1, 2013, Baltimore, MD
ICD9CM_2005ICD-9-CM [computer file]: international classification of diseases, ninth revision, clinical modification. Version 22. Baltimore, MD: U.S. Department of Health and Human Services, Centers for Medicare & Medicaid Services, effective October 1, 2004
ICPC93The International Classification of Primary Care (ICPC). Denmark: World Organisation of Family Doctors, 1993.
ICPCBAQ_1993The International Classification of Primary Care (ICPC). Basque Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCDAN_1993The International Classification of Primary Care (ICPC). Danish Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCDUT_1993The International Classification of Primary Care (ICPC). Dutch Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCFIN_1993The International Classification of Primary Care (ICPC). Finnish Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCFRE_1993The International Classification of Primary Care (ICPC). French Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCGER_1993The International Classification of Primary Care (ICPC). German Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCHEB_1993The International Classification of Primary Care (ICPC). Hebrew Translation, Denmark: World Organisation of Family Doctors, 1993.
ICPCHUN_1993The International Classification of Primary Care (ICPC). Hungarian Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCITA_1993The International Classification of Primary Care (ICPC). Italian Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCNOR_1993The International Classification of Primary Care (ICPC). Norwegian Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCPOR_1993The International Classification of Primary Care (ICPC). Portuguese Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCSPA_1993The International Classification of Primary Care (ICPC). Spanish Translation. Denmark: World Organisation of Family Doctors, 1993.
ICPCSWE_1993The International Classification of Primary Care (ICPC). Swedish Translation. Denmark: World Organisation of Family Doctors, 1993.
LCH90Library of Congress Subject Headings. 12th ed. Washington (DC): Library of Congress, 1989.
LCH_NW_2013Northwestern University Library, Library of Congress Subject Headings, Northwestern University subset, Evanston, IL, 2013.
LNC272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Version 2.72, Indianapolis (IN), February 16, 2022
LNC215Logical Observation Identifier Names and Codes (LOINC). Version 2.15. Indianapolis (IN): The Regenstrief Institute, June 6, 2005
LNC-DE-AT_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), German, Austria Edition, Version 2.72 Austria ELGA February 16, 2022, German
LNC-DE-DE_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), German, Germany Edition, Version 2.72 Germany Institute for Medical Documentation and Information (DIMDI) February 16, 2022, German
LNC-EL-GR_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Greek, Greece Edition, Version 2.72 Greece, Efstratia Kontaxi, MD, MSc, and Evripidis Stefanidis, MD, with technical support from Panagiotis Kontaxis, Diploma of Electrical and Computer Engineering, February 16, 2022, Greek
LNC-ES-AR_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Spanish, Argentina Edition, Version 2.72 Argentina Conceptum Medical Terminology Center February 16, 2022, Spanish
LNC-ES-ES_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Spanish, Spain Edition, Version 2.72 Spain, The Clinical Laboratory Committee of SERVICIO EXTREMENO DE SALUD, with the support of BITAC MAP. February 16, 2022, Spanish
LNC-ES-MX_272 (new)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Spanish, Mexico Edition, Version 2.72 Mexico, Deep Dive Data Science, February 16, 2022, Spanish
LNC-ET-EE_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Estonian, Estonia Edition, Version 2.72 Estonia Estonian E-Health Foundation February 16, 2022, Estonian
LNC-FR-BE_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), French, Belgium Edition, Version 2.72 Belgium Jean M. Prevost, MD, Biopathology February 16, 2022, French
LNC-FR-CA_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), French, Canada Edition, Version 2.72 Canada Canada Health Infoway Inc. February 16, 2022, French
LNC-FR-FR_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), French, France Edition, Version 2.72 France ASIP Sante (Agence des systemes d’information partages de de sante) February 16, 2022, French
LNC-IT-IT_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Italian, Italy Edition, Version 2.72 Italy Consiglio Nazionale delle Ricerche February 16, 2022, Italian
LNC-KO-KR_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Korean, Korea Edition, Version 2.72 Republic of Korea Korean Ministry for Health, Welfare, and Family Affairs February 16, 2022, Korean
LNC-NL-NL_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Dutch, Netherlands Edition, Version 2.72 Netherlands NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands February 16, 2022, Dutch
LNC-PL-PL_272 (new)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Polish, Poland Edition, Version 2.72 Poland, ;Polish Society of Laboratory Diagnostics, February 16, 2022, Polish
LNC-PT-BR_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Portuguese, Brazil Edition, Version 2.72 Brazil HL7 Brazil Institute February 16, 2022, Portuguese
LNC-RU-RU_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Russian, Russia Edition, Version 2.72 Russia Yaroslavl State Medical Academy February 16, 2022, Russian
LNC-TR-TR_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Turkish, Turkey Edition, Version 2.72 Turkey LOINC Turkish Translation Group and the Turkish Ministry of Health February 16, 2022, Turkish
LNC-ZH-CN_272 (updated)The Regenstrief Institute, Logical Observation Identifier Names and Codes (LOINC), Chinese, China Edition, Version 2.72 China, Lin Zhang, a LOINC volunteer from China February 16, 2022, Chinese
MCM92Glossary of Methodologic Terms for Clinical Epidemiologic Studies of Human Disorders. Canada: McMaster University, 1992
MEDLINEPLUS_20211023 (updated)MedlinePlus Health Topics, National Library of Medicine, October 23, 2021 Bethesda, MD
MEDLINEPLUS_SPA_20211023 (new)MedlinePlus Spanish Health Topics, National Library of Medicine, October 23, 2021 Bethesda, MD
MED-RT_2022_03_07 (updated)Medication Reference Terminology, Washington, DC, U.S. Department of Veterans Affairs, Veterans Health Administration, March 7, 2022
MSH2022_2022_01_24 (updated)Medical Subject Headings (MeSH), 2022, U.S. National Library of Medicine January 24, 2022, Bethesda, MD
MSH2015_2014_09_08Medical Subject Headings (MeSH), 2015, U.S. National Library of Medicine 2015, Bethesda, MD
MTHUMLS Metathesaurus. Bethesda, MD: National Library of Medicine
MTHCMSFRF_2020_22_03_07 (updated)Metathesaurus Forms of CMS Formulary Reference File, 2020 Bethesda, MD National Library Of Medicine
MTHICD9_2014Metathesaurus additional entry terms for ICD-9-CM [computer file]: International Classification of Diseases, Ninth Revision, Clinical Modification, National Library of Medicine, October 1, 2013, Bethesda, MD
MTHMST2001Metathesaurus Version of Minimal Standard Terminology Digestive Endoscopy. Bethesda, MD: National Library of Medicine, 2001
MTHMSTFRE_2001Metathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, French Translation. Bethesda, MD: National Library of Medicine, 2001
MTHMSTITA_2001Metathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, Italian Translation. Bethesda, MD: National Library of Medicine, 2001
MTHSPL_2022_02_25 (updated)Metathesaurus Forms of the FDA Structured Product Labels, 2022_02_25 Bethesda, MD National Library of Medicine
MVX2022_02_28 (updated)National Center for Immunization and Respiratory Diseases, Manufacturers of Vaccines, Atlanta, GA, February 28, 2022
NCBI2021_05_25NCBI Taxonomy, National Institutes of Health, National Library of Medicine, National Center for Biotechnology Information, May 25, 2021, Bethesda, MD
NCI2021_09D (updated)National Cancer Institute, National Institutes of Health, NCI Thesaurus, 21.09d, National Cancer Institute, September 27, 2021, Bethesda, MD
NCI2021_ACC-AHA_2109D (updated)American College of Cardiology/American Heart Association Clinical Data Terminology, 21.09d, September 27, 2021
NCI2021_BioC_2109D (updated)BioCarta online maps of molecular pathways, adapted for NCI use, 21.09d, September 27, 2021
NCI2021_BRIDG_2109D (updated)Biomedical Research Integrated Domain Group Model, 21.09d, September 27, 2021
NCI2021_BRIDG_5_3_2109D (updated)Biomedical Research Integrated Domain Group Model, 21.09d, September 27, 2021
NCI2021_caDSR_2109D (updated)Cancer Data Standards Registry and Repository, 21.09d, September 27, 2021
NCI2021_CareLex_2109D (updated)Content Archive Resource Exchange Lexicon, 21.09d, September 27, 2021
NCI2021_CBDD_2109D (updated)Chemical Biology and Drug Development Vocabulary, 21.09d, September 27, 2021
NCI2021_CDC_2109D (updated)U.S. Centers for Disease Control and Prevention, Department of Health and Human Services, 21.09d, September 27, 2021, Atlanta, GA
NCI2021_CDISC_2109D (updated)Clinical Data Interchange Standards Consortium, 21.09d, September 27, 2021
NCI2021_CDISC-GLOSS_2109D (updated)CDISC Glossary Terminology, 21.09d, September 27, 2021
NCI2021_CELLOSAURUS_2109D (updated)Cellosaurus, 21.09d, September 27, 2021
NCI2021_CRCH_2109D (updated)Cancer Research Center of Hawaii, University of Hawaii, Cancer Research Center of Hawaii Nutrition Terminology, 21.09d Hawaii, September 27, 2021
NCI2021_CTCAE_2109D (updated)Common Terminology Criteria for Adverse Events, 21.09d, September 27, 2021
NCI2021_CTCAE_3_2109D (updated)Common Terminology Criteria for Adverse Events 3.0, 21.09d, September 27, 2021
NCI2021_CTCAE_5_2109D (updated)Common Terminology Criteria for Adverse Events 5.0, 21.09d, September 27, 2021
NCI2021_CTDC_2109D (updated)Clinical Trial Data Commons, 21.09d, September 27, 2021
NCI2021_CTEP-SDC_2109D (updated)Cancer Therapy Evaluation Program - Simple Disease Classification, 21.09d, September 27, 2021
NCI2021_CTRP_2109D (updated)Clinical Trials Reporting Program, 21.09d, September 27, 2021
NCI2021_DCP_2109D (updated)NCI Division of Cancer Prevention Program, 21.09d, September 27, 2021
NCI2021_DICOM_2109D (updated)Digital Imaging Communications in Medicine, 21.09d, September 27, 2021
NCI2021_DTP_2109D (updated)National Cancer Institute, NCI Developmental Therapeutics Program, 21.09d, September 27, 2021
NCI2021_EDQM-HC_2109D (updated)European Directorate for the Quality of Medicines and Healthcare, 21.09d, September 27, 2021
NCI2021_FDA_2109D (updated)U.S. Food and Drug Administration, 21.09d, September 27, 2021
NCI2021_GAIA_2109D (updated)Brighton Collaboration Foundation (BCF), Global Alignment of Immunization Safety Assessment in pregnancy, 21.09d, September 27, 2021
NCI2021_GDC_2109D (updated)NCI Genomic Data Commons Terms, 21.09d, September 27, 2021
NCI2021_GENC_2109D (updated)Country Codes Working Group of the Geospatial Intelligence Standards Working Group (GWG), Geopolitical Entities, Names, and Codes (GENC) Standard Edition 1, 21.09d, September 27, 2021
NCI2021_ICH_2109D (updated)International Conference on Harmonization, 21.09d, September 27, 2021
NCI2021_INC_2109D (updated)International Neonatal Consortium Terms, 21.09d, September 27, 2021
NCI2021_JAX_2109D (updated)Jackson Laboratories, Jackson Laboratories Mouse Terminology, adapted for NCI use, 21.09d, September 27, 2021
NCI2021_KEGG_2109D (updated)Kyoto Encyclopedia of Genes and Genomes (KEGG), KEGG Pathway Database, adapted for NCI use, 21.09d, September 27, 2021
NCI2021_NCI-GLOSS_2109D (updated)National Cancer Institute, NCI Dictionary of Cancer Terms, 21.09d, September 27, 2021 Bethesda, MD
NCI2021_NCI-HGNC_2109D (updated)NCI HUGO Gene Nomenclature, 21.09d, September 27, 2021
NCI2021_NCI-HL7_2109D (updated)Health Level 7, NCI Health Level 7, 21.09d, September 27, 2021
NCI2021_NCPDP_2109D (updated)National Council for Prescription Drug Programs, 21.09d Scottsdale, AZ, September 27, 2021
NCI2021_NICHD_2109D (updated)National Institute of Child Health and Human Development, National Institutes of Health, 21.09d, September 27, 2021
NCI2021_PCDC_2109D (updated)Pediatric Cancer Data Commons, 21.09d Scottsdale, AZ, September 27, 2021
NCI2021_PID_2109D (updated)Carl F. Schaefer, Kira Anthony, Shiva Krupa, Jeffrey Buchoff, Matthew Day, Timo Hannay & Kenneth H. Buetow., PID: The Pathway Interaction Database, 21.09d, September 27, 2021
NCI2021_PI-RADS_2109D (updated)Prostate Imaging Reporting and Data System, 21.09d, September 27, 2021
NCI2021_RENI_2109D (updated)Registry Nomenclature Information System, 21.09d, September 27, 2021
NCI2021_UCUM_2109D (updated)Schadow, Gunther and McDonald, Clement, Regenstrief Institute, Inc. and The UCUM Organization, Unified Code for Units of Measure, 21.09d, September 27, 2021, Indianapolis, IN
NCI2021_ZFin_2109D (updated)Zebrafish Information Network (ZFIN), Zebrafish Model Organism Database, 21.09d University of Oregon, September 27, 2021, Eugene, OR
NCISEER_1999NCI Surveillance, Epidemiology, and End Results (SEER) conversions between ICD-9-CM and ICD-10 neoplasm codes. National Cancer Institute, Bethesda, MD. Release Date: June 1999
OMIM2022_01_24 (updated)McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), Online Mendelian Inheritance in Man (OMIM), Baltimore, MD McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, January 24, 2022
PDQ_2018_10_27PDQ. Bethesda MD: National Cancer Institute, October 27, 2018
QMR96Quick Medical Reference (QMR). San Bruno (CA): First DataBank, 1997
RAM99QMR clinically related terms from Randolf A. Miller, 1999
RXNORM_20AA_220307F (updated)RxNorm, META2020AA Full Update 2022_03_07 Bethesda, MD National Library of Medicine
SCTSPA_2021_10_31 (updated)SNOMED International, SNOMED CT Spanish Edition, Spanish Language Edition, London, United Kingdom, October 31, 2021
SNM2Cote, Roger A., Systematized Nomenclature of Medicine. 2nd ed. Skokie (IL): College of American Pathologists, 1982
SNMI98Cote, Roger A., Systematized Nomenclature of Human and Veterinary Medicine: SNOMED International, Version 3.5, Schaumberg (IL), College of American Pathologists, American Veterinary Medical Association, 1998
SNOMEDCT_US_2022_03_01 (updated)SNOMED International, US Edition of SNOMED CT, London, United Kingdom, SNOMED International, March 1, 2022
SNOMEDCT_US_2021_09_01 (updated)SNOMED International, US Edition of SNOMED CT, London, United Kingdom, SNOMED International, September 1, 2021
SNOMEDCT_US_2020_07_31SNOMED International, US Edition of SNOMED CT, London, United Kingdom, SNOMED International, July 31, 2020
SNOMEDCT_VET_2021_10_01 (updated)Veterinary Terminology Services Laboratory (VTSL),Virginia Maryland Regional College of Veterinary Medicine, Veterinary Extension to SNOMED CT, Blacksburg, VA, October 2021
SOP9.2 (updated)National Association of Health Data Organizations (NAHDO),Source of Payment Typology, Version 9.2, National Association of Health Data Organizations (NAHDO), December, 2020
SPN2003Standard Product Nomenclature (SPN). Rockville, (MD): U.S. Food and Drug Administration, 2003
SRCUMLS Metathesaurus Source Terminologies. Bethesda, MD: National Library of Medicine
TKMT2011Traditional Korean Medical Terms, 2011 Korea, KOR
USP_2022_02_15 (updated)USP Compendial Nomenclature, February, 2022, United States Pharmacopeia, February, 2022
USPMG_2020USP Medicare Model Guidelines, Version 6, United States Pharmacopeia February 1, 2020
UWDA173Jose Mejino, M.D., University of Washington Digital Anatomist, (UWDA). Seattle (WA): University of Washington, Version 1.7.3, March, 2003.
VANDF_2022_01_31 (updated)Veterans Health Administration National Drug File, January 31, 2022, Washington, DC U.S. Department of Veterans Affairs

Deidentified clinical records used in the development of this offering were provided by the i2b2 National Center for Biomedical Computing funded by U54LM008748 and were originally prepared for the Shared Tasks for Challenges in NLP for Clinical Data organized by Dr. Ozlem Uzuner, i2b2 and SUNY

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Nelson SJ, Zeng K, Kilbourne J, Powell T, Moore R. Normalized names for clinical drugs: RxNorm at 6 years. J Am Med Inform Assoc. 2011 Jul-Aug;18(4)441-8. doi: 10.1136/amiajnl-2011-000116. Epub 2011 Apr 21. PubMed PMID: 215544; PubMed Central PMCID: PMC3128404.